HitPredict

Interactor 1: COT1 (P10589)
COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3)
Gene: NR2F1

Interactor 2: NCOA2 (Q15596)
Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)
Gene: NCOA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10652338
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 1464
+	Hs
		587173 RXRA_HUMAN (6-410): 5.19e-127: 376: 36.61		NCOA2_HUMAN (1-1464): 0: 616: 100.00
+	Hs
		782551 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		NCOA2_HUMAN (1-1464): 0: 616: 100.00
+	Hs
		490120 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		NCOA3_HUMAN (1-1413): 4.69e-96: 342: 38.52
+	Hs
		587195 RXRA_HUMAN (6-410): 5.19e-127: 376: 36.61		NPAS2_HUMAN (20-883): 3.59e-105: 356: 15.58
+	Hs
		126103 RXRA_HUMAN (6-410): 5.19e-127: 376: 36.61		BMAL1_HUMAN (6-539): 3.91e-105: 350: 17.70
+	Hs
		490089 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		AHR_HUMAN (4-769): 3.6e-77: 276: 12.82
+	Hs
		587212 RXRA_HUMAN (6-410): 5.19e-127: 376: 36.61		NCOA3_HUMAN (1-1413): 4.69e-96: 342: 38.52
+	Hs
		782560 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		HIF1A_HUMAN (13-835): 8.2e-109: 366: 13.75
+	Hs
		126108 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		BMAL1_HUMAN (6-539): 3.91e-105: 350: 17.70
+	Hs
		500381 RARB_HUMAN (3-423): 6.26e-119: 355: 25.40		NCOA3_HUMAN (1-1413): 4.69e-96: 342: 38.52
+	Hs
		126099 RARA_HUMAN (3-417): 3.02e-115: 346: 25.41		BMAL1_HUMAN (6-539): 3.91e-105: 350: 17.70
+	Hs
		782708 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		NCOA3_HUMAN (1-1413): 4.69e-96: 342: 38.52
+	Hs
		181498 RXRA_HUMAN (6-410): 5.19e-127: 376: 36.61		CLOCK_HUMAN (7-863): 1.16e-82: 292: 15.71
+	Hs
		587177 RXRA_HUMAN (6-410): 5.19e-127: 376: 36.61		NCOA1_HUMAN (1-1460): 8.21e-80: 292: 28.32
+	Hs
		659718 RXRB_HUMAN (33-410): 1.02e-119: 360: 37.27		NCOA1_HUMAN (1-1460): 8.21e-80: 292: 28.32
+	Hs
		500364 RARB_HUMAN (3-423): 6.26e-119: 355: 25.40		NCOA1_HUMAN (1-1460): 8.21e-80: 292: 28.32
+	Hs
		782555 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		NCOA1_HUMAN (1-1460): 8.21e-80: 292: 28.32
+	Mm
		509308 RARA_MOUSE (3-420): 2.84e-116: 349: 25.23		NCOA1_MOUSE (1-1460): 1.91e-78: 288: 27.46
+	Hs
		649056 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		ARNT_HUMAN (4-664): 7.44e-75: 268: 14.99
+	Hs
		782595 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		KMT2C_HUMAN (670-1422): 5e-11: 70.1: 13.05