HitPredict

Interactor 1: HSP71 (P10591)
Heat shock protein SSA1 (Heat shock protein YG100)
Gene: SSA1

Interactor 2: HST3 (P53687)
NAD-dependent histone deacetylase HST3 (EC 2.3.1.286) (Homologous to SIR2 protein 3) (Regulatory protein SIR2 homolog 3)
Gene: HST3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36269765, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 642 Sc			1 447
+	Sc
		494586 HSP72_YEAST (1-642): 0: 922: 96.26		HST3_YEAST (1-447): 0: 539: 100.00
+	Hs
		714048 HS71L_HUMAN (2-642): 0: 949: 72.52		SIR1_HUMAN (31-431): 8.75e-104: 326: 25.78
+	Hs
		714080 HS71L_HUMAN (2-642): 0: 949: 72.52		SIR3_HUMAN (36-367): 1.25e-88: 277: 25.89
+	Sc
		416181 HSP71_YEAST (1-642): 0: 925: 100.00		SIR2_YEAST (1-370): 4.25e-90: 286: 24.29
+	Sc
		491991 HSP71_YEAST (1-642): 0: 925: 100.00		HST1_YEAST (26-362): 2.14e-90: 284: 27.22
+	Sc
		416182 HSP72_YEAST (1-642): 0: 922: 96.26		SIR2_YEAST (1-370): 4.25e-90: 286: 24.29
+	Hs
		504364 HSP7C_HUMAN (2-642): 0: 937: 73.91		SIR2_HUMAN (37-391): 2.72e-86: 270: 26.79
+	Sc
		491993 HSP71_YEAST (1-642): 0: 925: 100.00		HST4_YEAST (45-340): 6.4e-87: 271: 33.55
+	Sc
		494587 HSP72_YEAST (1-642): 0: 922: 96.26		HST4_YEAST (45-340): 6.4e-87: 271: 33.55
+	Hs
		871799 HSP72_HUMAN (2-642): 0: 923: 71.05		SIR7_HUMAN (8-392): 1.15e-84: 266: 20.10
+	Hs
		714019 HS71L_HUMAN (2-642): 0: 949: 72.52		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Hs
		504402 HSP7C_HUMAN (2-642): 0: 937: 73.91		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79
+	Hs
		871671 HSP72_HUMAN (2-642): 0: 923: 71.05		SIR6_HUMAN (17-385): 1.31e-72: 234: 19.79