HitPredict

Interactor 1: HSP72 (P10592)
Heat shock protein SSA2
Gene: SSA2

Interactor 2: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22940862, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 639 Sc			1 551
+	Sc
		492627 HSP71_YEAST (1-639): 0: 969: 97.04		HRD1_YEAST (1-551): 2.26e-158: 464: 100.00
+	Sc
		450211 HSP73_YEAST (1-639): 0: 961: 78.89		HRD1_YEAST (1-551): 2.26e-158: 464: 100.00
+	Hs
		504330 HSP7C_HUMAN (2-639): 0: 948: 74.34		SYVN1_HUMAN (7-481): 1.31e-90: 292: 20.63
+	Hs
		714092 HS71L_HUMAN (2-639): 0: 959: 72.08		AMFR_HUMAN (41-477): 3.96e-54: 195: 15.82
+	Hs
		713994 HS71L_HUMAN (2-639): 0: 959: 72.08		RNF43_HUMAN (221-519): 3.36e-35: 142: 11.44
+	Sc
		490368 HSP71_YEAST (1-639): 0: 969: 97.04		SAN1_YEAST (325-521): 3.77e-31: 129: 14.93
+	Sc
		492538 HSP71_YEAST (1-639): 0: 969: 97.04		IRC20_YEAST (133-437): 2.76e-29: 125: 11.73
+	Hs
		564092 HSP76_HUMAN (4-639): 0: 952: 70.58		RNF43_HUMAN (221-519): 3.36e-35: 142: 11.44
+	Hs
		504235 HSP7C_HUMAN (2-639): 0: 948: 74.34		RNF43_HUMAN (221-519): 3.36e-35: 142: 11.44
+	Hs
		714011 HS71L_HUMAN (2-639): 0: 959: 72.08		GOLI_HUMAN (273-483): 1.19e-30: 125: 17.84
+	Sp
		195220 HSP72_SCHPO (1-639): 0: 958: 77.74		DSC1_SCHPO (189-404): 2.98e-29: 124: 20.00
+	Hs
		871613 HSP72_HUMAN (2-639): 0: 933: 71.23		RNF43_HUMAN (221-519): 3.36e-35: 142: 11.44
+	Sc
		493226 HSP72_YEAST (1-639): 0: 935: 100.00		SAN1_YEAST (325-521): 3.77e-31: 129: 14.93
+	Sc
		495048 HSP72_YEAST (1-639): 0: 935: 100.00		IRC20_YEAST (133-437): 2.76e-29: 125: 11.73