HitPredict

Interactor 1: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 105 Hs			1 1342
+	Hs
		531718 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		495533 THIO_HUMAN (1-105): 6.33e-41: 132: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383556 THIO_HUMAN (1-105): 6.33e-41: 132: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337832 THIO_HUMAN (1-105): 6.33e-41: 132: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383571 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338707 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337778 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	At
		1107553 TRXH5_ARATH (2-104): 1.46e-34: 116: 35.24		WAK3_ARATH (327-986): 7.33e-133: 428: 14.78
+	Hs
		434126 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		435520 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		531732 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		423108 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Gg
		94428 THIO_CHICK (1-105): 3.19e-38: 125: 70.48		KSYK_CHICK (715-958): 2e-43: 170: 36.80
+	Hs
		411442 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		411285 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		411271 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Rn
		102493 G3V6T7_RAT (3-104): 2.36e-23: 94.4: 25.69		INSR_RAT (329-650): 1.42e-20: 101: 16.71
+	Hs
		537760 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51