HitPredict

Interactor 1: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Interactor 2: PRDX1 (Q06830)
Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
Gene: PRDX1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	33338048, 10843682, 17557078
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045454 - cell redox homeostasis and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 105 Hs			1 199
+	Hs
		495475 THIO_HUMAN (1-105): 6.33e-41: 132: 100.00		PRDX2_HUMAN (1-198): 2.38e-103: 297: 77.78
+	Mm
		727682 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX1_MOUSE (1-199): 1.07e-104: 301: 95.48
+	Mm
		956730 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX2_MOUSE (1-198): 1.73e-103: 298: 76.26
+	Hs
		685729 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		PRDX2_HUMAN (1-198): 2.38e-103: 297: 77.78
+	Mm
		589514 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX3_MOUSE (2-197): 9.94e-97: 283: 63.27
+	Mm
		139927 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX4_MOUSE (4-197): 1.04e-95: 281: 69.07
+	Hs
		531737 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		PRDX3_HUMAN (2-197): 1.85e-98: 287: 62.76
+	Hs
		1026726 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59
+	Sc
		606199 TRX1_YEAST (1-102): 8.34e-39: 126: 47.06		TSA1_YEAST (6-196): 4.55e-88: 258: 60.21
+	Sc
		611720 TRX2_YEAST (1-105): 1.08e-38: 126: 47.62		TSA1_YEAST (6-196): 4.55e-88: 258: 60.21
+	Hs
		531815 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59
+	So
		188731 TRXM_SPIOL (2-105): 1.38e-35: 120: 28.70		BAS1_SPIOL (8-196): 2.37e-86: 257: 60.00
+	Ss
		852832 THIO_SYNY3 (6-105): 1.71e-34: 115: 31.37		Y755_SYNY3 (6-196): 9.14e-89: 260: 57.29
+	Sc
		606220 TRX1_YEAST (1-102): 8.34e-39: 126: 47.06		TSA2_YEAST (6-196): 1.43e-83: 247: 59.16
+	Sc
		611752 TRX2_YEAST (1-105): 1.08e-38: 126: 47.62		TSA2_YEAST (6-196): 1.43e-83: 247: 59.16
+	At
		1280846 TRXF1_ARATH (2-102): 4.37e-33: 114: 41.18		BAS1A_ARATH (8-196): 2.48e-86: 257: 59.16
+	Dm
		1177773 THIO2_DROME (1-105): 5.65e-36: 119: 49.06		Q7JX87_DROME (6-197): 1.13e-74: 225: 32.20
+	Sc
		630634 TRX3_YEAST (2-104): 2.44e-35: 118: 41.75		PRX1_YEAST (5-197): 2.02e-67: 208: 33.17
+	Mm
		139705 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX6_MOUSE (4-197): 1.21e-68: 210: 29.47
+	Ss
		852787 THIO_SYNY3 (6-105): 1.71e-34: 115: 31.37		P73348_SYNY3 (5-197): 7.94e-69: 210: 28.64