HitPredict

Interactor 1: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.765

Property	Details
Experiments	23291592, 15696199, 25098452, 19805025, 9564042, 34837535, 22095282, 17724081, 17331951, 20385180, 19018770, 29186683, 29227477, 12089063, 11689443, 10843682, 19880523, 21771788
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 105 Hs			1 1374
+	Hs
		1305584 THIOM_HUMAN (5-105): 2.33e-34: 117: 35.92		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Mm
		192181 THIO_MOUSE (1-104): 1.79e-39: 128: 88.46		M3K5_MOUSE (1-1372): 0: 1451: 94.13
+	Hs
		160663 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Hs
		423182 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Hs
		423217 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		PAK2_HUMAN (686-960): 1.26e-97: 325: 31.27
+	Hs
		495474 THIO_HUMAN (1-105): 6.33e-41: 132: 100.00		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64