HitPredict

Interactor 1: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Interactor 2: TXNIP (Q9H3M7)
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Gene: TXNIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	10814541, 16766796, 17603038, 24198286, 16269462, 19018770, 19605364, 32296183, 10419473, 32901881, 34941434, 33460751, 21705327, 23519408, 21636804, 24389582, 28514442, 34085839, 23880345, 20023662 and 1 others more... unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, x-ray crystallography, biochemical, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arrestin_C~Thioredoxin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 105 Hs			1 391
+	Hs
		202683 TXNL1_HUMAN (2-105): 1.99e-36: 126: 40.39		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Hs
		1306343 THIOM_HUMAN (5-105): 2.33e-34: 117: 35.92		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Rn
		506352 THIO_RAT (1-104): 6.81e-39: 127: 89.42		ARRB1_RAT (25-313): 6.71e-56: 191: 12.61
+	Hs
		423157 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		ARRB2_HUMAN (15-323): 2.03e-60: 202: 12.18
+	Hs
		423173 PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22		ARRB1_HUMAN (25-358): 2.59e-56: 191: 12.95