HitPredict

Interactor 1: TGFB3 (P10600)
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
Gene: TGFB3

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.972

The method score is based on:

Property Details
Experiments 12729750, 11850637, 9872992, 11157754, 7878020, 18243111, 15017149, 21423151
Identification Methods pull down, x-ray crystallography, affinity chromatography technology, surface plasmon resonance, nuclear magnetic resonance, blue native page, ion exchange chromatography, molecular sieving
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TGF_beta~ecTbetaR2
Common GO terms GO:0001701 - in utero embryonic development
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007179 - transforming growth factor beta receptor signaling pathway
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 412
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024