HitPredict

Interactor 1: CP51 (P10614)
Lanosterol 14-alpha demethylase CYP51 (EC 1.14.14.154) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (CYPLI) (Ergosterol biosynthetic protein 11) (Lanosterol C14-C32 lyase) (Sterol 14-alpha demethylase)
Gene: ERG11

Interactor 2: CP51 (P10614)
Lanosterol 14-alpha demethylase CYP51 (EC 1.14.14.154) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (CYPLI) (Ergosterol biosynthetic protein 11) (Lanosterol C14-C32 lyase) (Sterol 14-alpha demethylase)
Gene: ERG11

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.815

The method score is based on:

Property Details
Experiments 18467557, 16300994
Identification Methods protein complementation assay, ubiquitin reconstruction, dihydrofolate reductase reconstruction
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains p450~p450
Common GO terms GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006696 - ergosterol biosynthetic process
GO:0008398 - sterol 14-demethylase activity
and 2 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 530
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1 530
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Last updated: 15 Jul 2024