HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26269332, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0036464 - cytoplasmic ribonucleoprotein granule
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 636
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (1-636): 0: 579: 99.53
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (1-636): 0: 579: 99.53
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (1-636): 2.98e-174: 511: 79.25
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		496405 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57
+	Hs
		496269 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Mm
		497953 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51
+	Mm
		449409 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		NUCL_MOUSE (166-386): 2.07e-20: 97.6: 19.56
+	Hs
		582292 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		582417 PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33