HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	35063084, 21339331
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 892
+	Hs
		211474 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN4_HUMAN (11-892): 0: 642: 86.74
+	Hs
		503257 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTN1_HUMAN (1-892): 0: 697: 100.00
+	Hs
		164558 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42
+	Hs
		496865 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17
+	Hs
		497586 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN4_HUMAN (173-588): 8.58e-09: 62: 10.82
+	Rn
		582039 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN2_RAT (225-763): 1.41e-14: 80.8: 13.69
+	Rn
		94264 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN2_RAT (225-763): 1.41e-14: 80.8: 13.69
+	Dm
		54271 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1Z9I8_DROME (236-822): 1.49e-11: 70.8: 10.32