HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36634849, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 745
+	Hs
		496430 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Rn
		582019 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PLAK_RAT (1-745): 0: 551: 97.99
+	Rn
		94245 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PLAK_RAT (1-745): 0: 551: 97.99
+	Hs
		542170 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		152599 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		554276 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		239029 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Dm
		578747 Q9VPR2_DROME (127-757): 2.65e-20: 98.2: 10.23		ARM_DROME (2-730): 6.94e-161: 488: 60.33
+	Hs
		134829 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IMA3_HUMAN (228-670): 2.7e-65: 227: 16.01
+	Hs
		131372 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79
+	Hs
		496611 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06
+	Hs
		496610 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32
+	Hs
		238627 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IMA7_HUMAN (262-685): 3.97e-45: 172: 13.86
+	Hs
		168613 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IMA6_HUMAN (273-659): 3.11e-41: 160: 13.95
+	Hs
		239044 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Hs
		497267 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARMC8_HUMAN (135-530): 3.88e-16: 84.5: 19.12