HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ERF3A (P15170)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)
Gene: GSPT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 499
+	Hs
		497278 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ERF3B_HUMAN (1-499): 0: 558: 93.79
+	Hs
		496815 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EF1A1_HUMAN (70-498): 1.24e-175: 503: 38.29
+	Hs
		497171 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EF1A3_HUMAN (70-498): 1.07e-174: 501: 38.06
+	Hs
		496901 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EF1A2_HUMAN (70-498): 6.64e-174: 499: 37.16
+	Rn
		581966 TAU_RAT (1-758): 4.86e-75: 260: 71.47		EF1A2_RAT (70-498): 1.12e-173: 498: 37.16
+	Rn
		94189 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		EF1A2_RAT (70-498): 1.12e-173: 498: 37.16
+	Mm
		486083 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		EF1A1_MOUSE (70-498): 1.27e-175: 503: 38.29
+	Dm
		1369275 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VK85_DROME (1-496): 9.26e-177: 512: 66.47