HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	9592050, 18467332
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1265
+	Hs
		496268 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Hs
		580935 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Hs
		497050 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCB4_HUMAN (822-1222): 6.23e-95: 333: 22.52
+	Hs
		496595 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCD1_HUMAN (574-1188): 5.13e-98: 332: 20.53
+	Hs
		497635 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCB1_HUMAN (837-1241): 1.26e-94: 332: 25.59
+	Dm
		632600 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		PIP1_DROME (909-1235): 4.76e-91: 323: 29.79