HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11104762
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 672
+	Hs
		408538 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Rn
		581978 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KPCB_RAT (1-664): 0: 747: 79.34
+	Rn
		94201 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KPCB_RAT (1-664): 0: 747: 79.34
+	Hs
		397126 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCG_HUMAN (1-670): 0: 706: 68.94
+	Mm
		497997 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KPCG_MOUSE (16-670): 0: 698: 69.88
+	Hs
		496879 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCE_HUMAN (8-664): 0: 635: 44.61
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (242-660): 9.73e-156: 459: 39.13
+	Hs
		116961 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		496492 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08
+	Hs
		496900 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCZ_HUMAN (22-98): 3.2e-11: 68.6: 34.44
+	Hs
		554297 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		KPCD_HUMAN (9-167): 3.67e-57: 207: 39.65