HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SYN1 (P17600)
Synapsin-1 (Brain protein 4.1) (Synapsin I)
Gene: SYN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26402096
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0019901 - protein kinase binding GO:0030424 - axon GO:0030425 - dendrite GO:0044297 - cell body and 1 others more... GO:0050808 - synapse organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 705
+	Hs
		497380 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYN2_HUMAN (1-448): 0: 593: 64.10
+	Rn
		582009 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYN2_RAT (1-515): 0: 568: 59.00
+	Rn
		94234 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYN2_RAT (1-515): 0: 568: 59.00
+	Rn
		456749 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYN1_RAT (1-705): 6.73e-169: 502: 96.03
+	Rn
		94125 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYN1_RAT (1-705): 6.73e-169: 502: 96.03
+	Mm
		292463 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		SYN1_MOUSE (1-705): 2.33e-173: 514: 96.03
+	Hs
		203203 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYNJ1_HUMAN (290-705): 2.31e-41: 165: 16.89
+	Hs
		302246 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SC31A_HUMAN (337-705): 2.53e-26: 117: 14.71
+	Hs
		497383 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CBP_HUMAN (394-705): 4.92e-11: 68.8: 14.97
+	Hs
		496630 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SC24C_HUMAN (460-704): 1.13e-10: 67.3: 16.42
+	Rn
		582007 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYNJ1_RAT (336-704): 6e-10: 65: 13.91
+	Rn
		94231 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYNJ1_RAT (336-704): 6e-10: 65: 13.91
+	Mm
		88453 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		D3Z656_MOUSE (346-690): 8.34e-12: 71.1: 11.71
+	Hs
		1056910 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CBP_HUMAN (394-705): 4.92e-11: 68.8: 14.97
+	Hs
		152675 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		CBP_HUMAN (394-705): 4.92e-11: 68.8: 14.97
+	Hs
		152667 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		KMT2C_HUMAN (348-705): 2.49e-09: 63: 10.70
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (335-700): 7.49e-09: 61.5: 7.16
+	Mm
		1207212 NCOA6_MOUSE (23-739): 1.31e-24: 112: 9.76		KMT2C_MOUSE (348-704): 8.53e-09: 61.5: 9.44
+	Hs
		1170076 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		CBP_HUMAN (394-705): 4.92e-11: 68.8: 14.97
+	Mm
		1351630 PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66		PCLO_MOUSE (329-705): 4.41e-09: 62.3: 13.32