HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SYT1 (P21579)
Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)
Gene: SYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030424 - axon GO:0043005 - neuron projection
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 422
+	Hs
		497309 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT2_HUMAN (2-422): 2.62e-113: 340: 74.47
+	Rn
		581931 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYT2_RAT (2-422): 7.09e-113: 339: 73.94
+	Rn
		94153 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYT2_RAT (2-422): 7.09e-113: 339: 73.94
+	Hs
		207687 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT7_HUMAN (16-278): 1.62e-40: 150: 23.27
+	Hs
		497164 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT6_HUMAN (15-277): 8.25e-33: 131: 20.96
+	Hs
		129078 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SYT5_HUMAN (18-241): 9.84e-29: 117: 20.17
+	Rn
		581944 TAU_RAT (1-758): 4.86e-75: 260: 71.47		RP3A_RAT (22-282): 1.15e-39: 152: 24.29
+	Rn
		94168 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		RP3A_RAT (22-282): 1.15e-39: 152: 24.29