HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: VDAC1 (P21796)
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
Gene: VDAC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 283
+	Hs
		496510 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		VDAC2_HUMAN (1-283): 4.13e-118: 342: 74.56
+	Hs
		2006 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		A0A0A0MR02_HUMAN (1-271): 5e-111: 323: 74.91
+	Hs
		497832 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		VDAC3_HUMAN (1-283): 1.29e-105: 310: 67.49
+	Rn
		581979 TAU_RAT (1-758): 4.86e-75: 260: 71.47		VDAC2_RAT (1-283): 2.31e-119: 345: 73.85
+	Rn
		94202 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		VDAC2_RAT (1-283): 2.31e-119: 345: 73.85
+	Rn
		582043 TAU_RAT (1-758): 4.86e-75: 260: 71.47		VDAC3_RAT (1-283): 2.18e-107: 314: 66.43
+	Rn
		94267 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		VDAC3_RAT (1-283): 2.18e-107: 314: 66.43
+	Mm
		498040 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		VDAC1_MOUSE (1-283): 9.77e-112: 326: 98.59
+	Mm
		498039 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		VDAC3_MOUSE (1-283): 2.16e-105: 309: 67.49
+	Hs
		330627 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TOM40_HUMAN (4-279): 5.43e-60: 196: 12.46
+	Hs
		799994 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		VDAC2_HUMAN (1-283): 4.13e-118: 342: 74.56
+	Hs
		601247 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		VDAC1_HUMAN (1-283): 1.37e-110: 322: 100.00