HitPredict

Interactor 1: RHG10 (A1A4S6)
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
Gene: ARHGAP10

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11432776, 32203420
Identification Methods	enzymatic study, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 786 Hs			1 193
+	Hs
		49630 RHG10_HUMAN (1-786): 0: 602: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		901048 RHG26_HUMAN (1-786): 6.21e-178: 532: 53.17		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		894587 RHG26_HUMAN (1-786): 6.21e-178: 532: 53.17		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		63073 RHG42_HUMAN (1-746): 5.36e-154: 473: 50.13		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		245183 OPHN1_HUMAN (1-758): 1.77e-153: 469: 42.90		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		245184 OPHN1_HUMAN (1-758): 1.77e-153: 469: 42.90		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		63065 RHG42_HUMAN (1-746): 5.36e-154: 473: 50.13		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		245182 OPHN1_HUMAN (1-758): 1.77e-153: 469: 42.90		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		63072 RHG42_HUMAN (1-746): 5.36e-154: 473: 50.13		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		925354 RHG17_HUMAN (130-748): 6.51e-85: 290: 15.74		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894126 RHG17_HUMAN (130-748): 6.51e-85: 290: 15.74		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		901000 RHG23_HUMAN (386-730): 1.33e-78: 278: 25.34		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925690 RHG23_HUMAN (386-730): 1.33e-78: 278: 25.34		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		915753 RHG17_HUMAN (130-748): 6.51e-85: 290: 15.74		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		925314 RHG44_HUMAN (130-745): 3.2e-77: 268: 15.18		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		900637 SRGP1_HUMAN (21-733): 8.39e-74: 262: 15.23		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925395 SRGP1_HUMAN (21-733): 8.39e-74: 262: 15.23		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894068 RHG44_HUMAN (130-745): 3.2e-77: 268: 15.18		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		200213 SRGP3_HUMAN (21-732): 7.37e-71: 254: 14.46		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Mm
		892733 SRGP1_MOUSE (21-732): 3.42e-70: 251: 15.54		CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33