HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KS6B1 (P23443)
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)
Gene: RPS6KB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.666

Property	Details
Experiments	16364302, 17512525
Identification Methods	enzymatic study, affinity chromatography technology, anti bait coimmunoprecipitation, protein kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0043005 - neuron projection and 1 others more... GO:0051721 - protein phosphatase 2A binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 525
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (3-416): 5.02e-151: 442: 38.66
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90
+	Hs
		408538 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCB_HUMAN (35-422): 2.03e-146: 437: 36.92
+	Hs
		496879 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCE_HUMAN (13-420): 6.39e-143: 430: 33.89
+	Hs
		496245 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCA_HUMAN (4-419): 2.83e-142: 426: 35.55
+	Hs
		496248 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCA_HUMAN (80-397): 6.73e-143: 417: 36.79
+	Rn
		581978 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KPCB_RAT (35-422): 4.52e-146: 436: 36.92
+	Rn
		94201 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KPCB_RAT (35-422): 4.52e-146: 436: 36.92
+	Hs
		270366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A5_HUMAN (4-349): 1.07e-103: 330: 24.73
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (3-405): 3.09e-104: 330: 24.04
+	Hs
		497071 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A1_HUMAN (6-405): 2.39e-104: 330: 23.79
+	Hs
		116961 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGK1_HUMAN (79-417): 5.26e-101: 312: 46.44
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90
+	Hs
		503261 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCA_HUMAN (80-397): 6.73e-143: 417: 36.79
+	Bt
		337290 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		KAPCA_BOVIN (80-397): 2.35e-142: 415: 37.11
+	Hs
		1057021 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		KS6A6_HUMAN (3-412): 3.24e-101: 322: 22.75