HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0010629 - negative regulation of gene expression GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1241
+	Hs
		496276 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT2B1_HUMAN (1-1241): 0: 1148: 72.46
+	Mm
		100205 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		F7AAP4_MOUSE (1-1144): 0: 1119: 86.29
+	Mm
		498086 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8C048_MOUSE (1-1103): 0: 1114: 78.13
+	Dm
		1359876 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9V4C7_DROME (16-1202): 0: 1051: 59.02
+	Mm
		223146 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AT2A2_MOUSE (45-1066): 0: 828: 27.01
+	Hs
		496196 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT1A3_HUMAN (27-1052): 0: 766: 24.34
+	Hs
		496589 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT1A2_HUMAN (35-1053): 0: 753: 23.60
+	Hs
		392995 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT1A1_HUMAN (34-1053): 0: 737: 23.37
+	Hs
		496237 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT2A2_HUMAN (45-1066): 0: 733: 25.98
+	Rn
		416169 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AT1A3_RAT (28-1052): 0: 764: 24.36
+	Rn
		94114 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AT1A3_RAT (28-1052): 0: 764: 24.36
+	Rn
		416147 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AT1A1_RAT (34-1053): 0: 739: 23.28
+	Rn
		94112 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AT1A1_RAT (34-1053): 0: 739: 23.28
+	Rn
		513722 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AT2A2_RAT (45-1066): 0: 732: 25.98
+	Rn
		94131 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AT2A2_RAT (45-1066): 0: 732: 25.98
+	Hs
		561576 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		AT2A2_HUMAN (45-1066): 0: 733: 25.98