HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	19014373, 35760815
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 298
+	Hs
		414701 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		496859 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Mm
		497948 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		CDK5_MOUSE (1-292): 1.87e-138: 394: 59.39
+	Hs
		414755 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Mm
		581220 NFH_MOUSE (284-730): 4.84e-16: 84.7: 14.99		CDK5_MOUSE (1-292): 1.87e-138: 394: 59.39
+	Rn
		974742 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		CDK5_RAT (1-292): 7.65e-138: 392: 59.39
+	Dm
		820723 CPN_DROME (345-756): 7.29e-11: 67.8: 11.17		CDK5_DROME (1-288): 3.01e-134: 383: 57.79