HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0016607 - nuclear speck GO:0019899 - enzyme binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 475
+	Mm
		497928 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		U2AF2_MOUSE (1-475): 2.34e-94: 295: 99.79
+	Hs
		497082 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79
+	Hs
		496937 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42
+	Hs
		497020 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV3_HUMAN (127-472): 9.26e-67: 220: 13.98
+	Hs
		497019 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		496346 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV4_HUMAN (88-342): 7.66e-39: 146: 13.33
+	Hs
		496405 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TIA1_HUMAN (253-475): 5.63e-36: 138: 15.70
+	Hs
		554269 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00
+	Hs
		497752 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35
+	Mm
		498050 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ELAV4_MOUSE (88-342): 7.66e-39: 146: 13.33
+	Mm
		497953 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TIA1_MOUSE (253-475): 4.2e-36: 139: 15.70
+	Rn
		582044 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PUF60_RAT (92-474): 7.77e-23: 103: 21.96
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (41-247): 4.23e-19: 92.3: 14.35
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (41-247): 4.23e-19: 92.3: 14.35
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (41-259): 3.41e-17: 86.5: 13.19
+	Hs
		1054314 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35