HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ELAV4 (P26378)
ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)
Gene: ELAVL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030424 - axon GO:0030425 - dendrite GO:0030426 - growth cone GO:1990090 - cellular response to nerve growth factor stimulus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 385
+	Hs
		496937 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV2_HUMAN (13-385): 6.39e-93: 284: 82.31
+	Hs
		497020 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV3_HUMAN (8-385): 6.91e-88: 271: 75.93
+	Mm
		498050 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ELAV4_MOUSE (1-385): 1.84e-107: 322: 99.74
+	Hs
		497205 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RBMS3_HUMAN (49-221): 8.52e-23: 100: 37.43
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (7-239): 9.36e-41: 154: 20.58
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (292-383): 7.71e-21: 96.3: 21.74
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (292-383): 1.1e-20: 95.9: 21.74
+	Hs
		497082 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV1_HUMAN (122-215): 1.57e-15: 78.6: 32.98
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (292-383): 8.69e-21: 95.9: 21.74
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (292-383): 8.69e-21: 95.9: 21.74
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (292-383): 7.71e-21: 96.3: 21.74