HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.731

Property	Details
Experiments	15650334, 36634849, 32812023, 35063084, 26269332, unassigned1973
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, two hybrid fragment pooling approach, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 245
+	Hs
		496737 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		496795 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		496415 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Rn
		581965 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433E_RAT (2-243): 1.31e-144: 406: 63.53
+	Rn
		94188 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433E_RAT (2-243): 1.31e-144: 406: 63.53
+	Rn
		581974 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433Z_RAT (1-245): 3.06e-142: 399: 80.00
+	Rn
		94197 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433Z_RAT (1-245): 3.06e-142: 399: 80.00
+	Rn
		581977 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433T_RAT (1-245): 2.96e-141: 397: 99.59
+	Rn
		94200 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433T_RAT (1-245): 2.96e-141: 397: 99.59
+	Mm
		497973 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Mm
		497995 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00
+	Hs
		496416 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		496898 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		496727 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Mm
		498123 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433B_MOUSE (1-242): 2.84e-124: 354: 80.99
+	Rn
		581964 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433G_RAT (1-242): 5.48e-105: 305: 70.33
+	Rn
		94187 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433G_RAT (1-242): 5.48e-105: 305: 70.33
+	Mm
		250865 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433S_MOUSE (1-232): 2e-106: 309: 72.65
+	Mm
		498003 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433F_MOUSE (2-242): 4.62e-106: 308: 71.43
+	Mm
		497971 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433G_MOUSE (1-242): 5.48e-105: 305: 70.33