HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	23666762, 35063084
Identification Methods	fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 753
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (2-753): 0: 626: 59.90
+	Hs
		497702 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK1_HUMAN (1-753): 0: 619: 62.89
+	Hs
		497452 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK4_HUMAN (1-753): 0: 612: 60.24
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (1-753): 0: 769: 100.00
+	Hs
		497023 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MELK_HUMAN (47-753): 2.32e-173: 514: 27.65
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (1-753): 0: 612: 60.24
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (1-753): 0: 612: 60.24
+	Hs
		496670 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK1_HUMAN (34-672): 2.85e-143: 441: 30.99
+	Hs
		497840 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK3_HUMAN (53-364): 1.13e-113: 375: 58.13
+	Hs
		497272 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		BRSK2_HUMAN (47-500): 2.68e-79: 271: 36.11