HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PRDX6 (P30041)
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)
Gene: PRDX6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	36634849, 32812023, 35063084
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 224
+	Hs
		496419 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRDX2_HUMAN (2-204): 9.19e-90: 264: 28.99
+	Hs
		496908 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRDX1_HUMAN (2-204): 1.79e-87: 258: 28.37
+	Hs
		496385 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRDX3_HUMAN (6-204): 4.06e-86: 257: 25.12
+	Hs
		496950 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRDX4_HUMAN (3-204): 2.98e-83: 250: 24.76
+	Mm
		139700 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PRDX6_MOUSE (1-224): 2.37e-103: 299: 89.73
+	Mm
		498041 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PRDX2_MOUSE (2-204): 3.36e-90: 265: 28.99
+	Dm
		1358961 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		PRDX2_DROME (6-203): 1.66e-82: 245: 28.71