HitPredict

Interactor 1: RHG10 (A1A4S6)
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
Gene: ARHGAP10

Interactor 2: PKN3 (Q6P5Z2)
Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)
Gene: PKN3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.838

Property	Details
Experiments	11432776, 32707033
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 786 Hs			1 889
+	Hs
		1160307 RHG26_HUMAN (1-786): 6.21e-178: 532: 53.17		PKN3_HUMAN (1-889): 0: 974: 100.00
+	Hs
		1035111 MYO9B_HUMAN (4-769): 2.92e-69: 251: 13.68		PKN2_HUMAN (13-884): 0: 894: 49.26
+	Hs
		566393 ACAP1_HUMAN (5-453): 2.47e-72: 253: 18.38		KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65
+	Hs
		681853 ACAP1_HUMAN (5-453): 2.47e-72: 253: 18.38		AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72
+	Hs
		682217 DP13A_HUMAN (2-378): 4.83e-68: 240: 17.69		AKT2_HUMAN (431-883): 8.79e-159: 474: 35.15
+	Hs
		682064 DP13A_HUMAN (2-378): 4.83e-68: 240: 17.69		AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72
+	Hs
		1356444 DP13A_HUMAN (2-378): 4.83e-68: 240: 17.69		AKT3_HUMAN (431-883): 9.46e-158: 472: 35.29
+	Mm
		554952 RGAP1_MOUSE (57-656): 2e-67: 236: 16.01		KPCE_MOUSE (476-887): 3.83e-148: 456: 37.35
+	Hs
		682206 RGAP1_HUMAN (389-567): 4.96e-20: 97.1: 35.71		AKT2_HUMAN (431-883): 8.79e-159: 474: 35.15