HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KAP3 (P31323)
cAMP-dependent protein kinase type II-beta regulatory subunit
Gene: PRKAR2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36634849, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043025 - neuronal cell body GO:0043197 - dendritic spine
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 418
+	Hs
		496203 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAP2_HUMAN (3-413): 1.93e-125: 370: 64.81
+	Hs
		503267 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAP3_HUMAN (1-418): 3.91e-140: 408: 100.00
+	Bt
		679326 Q28869_BOVIN (402-758): 4.55e-32: 129: 41.34		KAP3_BOVIN (1-418): 1.79e-138: 404: 97.37
+	Bt
		337286 Q28869_BOVIN (402-758): 4.55e-32: 129: 41.34		KAP2_BOVIN (3-416): 1.89e-128: 377: 65.06
+	Hs
		503259 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAP2_HUMAN (3-413): 1.93e-125: 370: 64.81
+	Hs
		496157 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAP0_HUMAN (102-276): 8.25e-24: 103: 24.72