HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	36931259, 26402096, 28575131, 35063084
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation, pull down, comigration in non denaturing gel electrophoresis, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 248
+	Hs
		496737 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		496795 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Mm
		250865 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433S_MOUSE (1-248): 4.84e-154: 429: 97.58
+	Rn
		581965 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433E_RAT (2-246): 4.41e-146: 410: 60.41
+	Rn
		94188 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433E_RAT (2-246): 4.41e-146: 410: 60.41
+	Mm
		497973 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433E_MOUSE (2-246): 4.41e-146: 410: 60.41
+	Rn
		581974 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433Z_RAT (1-243): 1.34e-136: 385: 69.96
+	Rn
		94197 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433Z_RAT (1-243): 1.34e-136: 385: 69.96
+	Mm
		497995 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96
+	Hs
		496356 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		496415 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		496727 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		496898 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Rn
		581977 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433T_RAT (1-238): 7.63e-107: 310: 71.43
+	Rn
		94200 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433T_RAT (1-238): 7.63e-107: 310: 71.43
+	Rn
		581964 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433G_RAT (1-242): 1.86e-98: 289: 65.16
+	Rn
		94187 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433G_RAT (1-242): 1.86e-98: 289: 65.16
+	Mm
		498123 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Mm
		497971 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Mm
		498003 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433F_MOUSE (2-242): 1.72e-96: 284: 64.20