HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	22343013, 18500754, 35760815, 35063084, 14962978, 21985244, 23271055, 29274099, 33139698
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 840
+	Hs
		320800 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Rn
		291980 TAU_RAT (1-758): 4.86e-75: 260: 71.47		HSP74_RAT (1-840): 0: 979: 95.83
+	Rn
		94108 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		HSP74_RAT (1-840): 0: 979: 95.83
+	Hs
		497367 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Mm
		498021 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q3U2G2_MOUSE (1-840): 0: 970: 95.61
+	Mm
		497946 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS74L_MOUSE (1-840): 0: 962: 61.91
+	Mm
		498049 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS105_MOUSE (1-840): 0: 932: 61.56
+	Hs
		554275 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Dm
		1370298 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VUC1_DROME (1-840): 0: 821: 42.10
+	Hs
		496165 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483743 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS71A_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		496425 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		496242 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Mm
		497918 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS71L_MOUSE (486-692): 1.89e-19: 95.5: 17.21
+	Mm
		497989 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15
+	Mm
		498048 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS71A_MOUSE (571-686): 1e-17: 89.7: 23.08
+	Hs
		503487 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92