HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26269332, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051260 - protein homooligomerization and 1 others more... GO:1990000 - amyloid fibril formation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 526
+	Hs
		497384 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		496876 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		212098 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HTSF1_HUMAN (267-372): 6.19e-23: 104: 21.30
+	Mm
		498083 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Mm
		498044 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		EWS_MOUSE (3-451): 2.8e-30: 127: 35.56
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		496630 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (184-382): 1.94e-12: 71.6: 12.44
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (184-382): 1.94e-12: 71.6: 12.44
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (220-382): 2.82e-12: 71.2: 15.95
+	Hs
		726817 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		967173 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		967541 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44