HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ARL3 (P36405)
ADP-ribosylation factor-like protein 3
Gene: ARL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008017 - microtubule binding GO:0015630 - microtubule cytoskeleton
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 182
+	Rn
		581981 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ARF2_RAT (13-181): 5.68e-88: 257: 44.38
+	Rn
		94204 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ARF2_RAT (13-181): 5.68e-88: 257: 44.38
+	Hs
		496257 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARF4_HUMAN (1-180): 1.54e-72: 218: 40.56
+	Hs
		496843 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARF5_HUMAN (1-180): 9.14e-72: 216: 41.67
+	Hs
		496764 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB1A_HUMAN (7-180): 6.93e-70: 212: 20.67
+	Hs
		497581 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB1B_HUMAN (10-180): 6.74e-69: 209: 20.46
+	Hs
		496707 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARF3_HUMAN (1-181): 2.29e-65: 199: 43.65
+	Hs
		496842 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARF1_HUMAN (1-181): 3.71e-65: 199: 43.09
+	Hs
		497091 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RB11B_HUMAN (7-179): 1.37e-64: 199: 18.54
+	Hs
		496754 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RB11A_HUMAN (7-179): 1.98e-64: 198: 18.54
+	Rn
		581962 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ARF3_RAT (1-181): 2.29e-65: 199: 43.65
+	Rn
		94185 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ARF3_RAT (1-181): 2.29e-65: 199: 43.65
+	Hs
		496478 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARL1_HUMAN (16-181): 2.92e-49: 159: 45.18
+	Mm
		497968 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ARF4_MOUSE (1-180): 1.35e-70: 213: 40.56
+	Mm
		497979 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB1A_MOUSE (7-180): 6.93e-70: 212: 20.67
+	Mm
		498132 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB1B_MOUSE (10-180): 1.58e-68: 208: 20.46
+	Dm
		897470 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		ARF1_DROME (1-178): 1.04e-64: 198: 43.82