HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MDHC (P40925)
Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)
Gene: MDH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 334
+	Hs
		334115 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		LDHA_HUMAN (6-330): 8.97e-122: 355: 20.73
+	Hs
		421952 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		LDHB_HUMAN (6-329): 5.72e-116: 340: 20.80
+	Rn
		581942 TAU_RAT (1-758): 4.86e-75: 260: 71.47		LDHB_RAT (6-329): 2.69e-116: 341: 20.80
+	Rn
		94166 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		LDHB_RAT (6-329): 2.69e-116: 341: 20.80
+	Hs
		496482 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MDHM_HUMAN (6-333): 2.56e-51: 174: 20.82
+	Dm
		1369704 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VKX2_DROME (1-333): 2.23e-114: 336: 66.37