HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: IF2G (P41091)
Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)
Gene: EIF2S3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26269332, 36634849, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 472
+	Hs
		496815 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EF1A1_HUMAN (35-465): 8.3e-123: 367: 17.88
+	Hs
		497171 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EF1A3_HUMAN (35-465): 1.87e-122: 367: 17.88
+	Hs
		496901 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EF1A2_HUMAN (35-465): 2.98e-122: 366: 17.46
+	Hs
		496557 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EFTU_HUMAN (28-466): 4.26e-120: 360: 22.79
+	Hs
		496223 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ERF3A_HUMAN (29-464): 5.18e-119: 359: 15.47
+	Rn
		581966 TAU_RAT (1-758): 4.86e-75: 260: 71.47		EF1A2_RAT (35-465): 4.03e-122: 365: 17.46
+	Rn
		94189 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		EF1A2_RAT (35-465): 4.03e-122: 365: 17.46
+	Rn
		581984 TAU_RAT (1-758): 4.86e-75: 260: 71.47		EFTU_RAT (1-466): 1.99e-120: 361: 21.46
+	Rn
		94207 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		EFTU_RAT (1-466): 1.99e-120: 361: 21.46
+	Mm
		486083 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		EF1A1_MOUSE (35-465): 8.66e-123: 367: 17.88
+	Mm
		498073 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		EFTU_MOUSE (1-466): 9.83e-121: 362: 21.46