HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11104762
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0015630 - microtubule cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 596
+	Hs
		496900 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Hs
		496879 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCE_HUMAN (43-590): 1.72e-177: 521: 36.23
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		496317 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6B1_HUMAN (215-594): 1.3e-145: 432: 35.94
+	Hs
		270366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A5_HUMAN (62-540): 2.04e-118: 371: 17.96
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47
+	Hs
		554297 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		408538 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		496245 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37
+	Hs
		397126 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCG_HUMAN (107-190): 1.32e-12: 72.8: 39.29
+	Rn
		581978 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KPCB_RAT (111-229): 6.26e-18: 89.6: 21.28
+	Rn
		94201 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KPCB_RAT (111-229): 6.26e-18: 89.6: 21.28
+	Mm
		497997 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KPCG_MOUSE (126-190): 1.85e-12: 72.4: 43.08