HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ACTY (P42025)
Beta-centractin (Actin-related protein 1B) (ARP1B)
Gene: ACTR1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0015630 - microtubule cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 376
+	Hs
		496704 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTZ_HUMAN (1-376): 0: 728: 90.43
+	Mm
		498099 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ACTY_MOUSE (1-376): 0: 772: 98.94
+	Rn
		581983 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ACTZ_RAT (1-376): 0: 728: 90.43
+	Rn
		94206 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ACTZ_RAT (1-376): 0: 728: 90.43
+	Mm
		497963 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ACTZ_MOUSE (1-376): 0: 728: 90.43
+	Hs
		496683 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTB_HUMAN (8-376): 0: 581: 53.62
+	Hs
		496806 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTG_HUMAN (7-376): 0: 581: 53.74
+	Hs
		496813 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTC_HUMAN (5-376): 0: 577: 53.72
+	Hs
		496759 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTA_HUMAN (5-376): 0: 576: 53.46
+	Hs
		496816 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTS_HUMAN (5-376): 0: 576: 53.19
+	Mm
		498001 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ACTC_MOUSE (5-376): 0: 577: 53.72
+	Hs
		503276 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTB_HUMAN (8-376): 0: 581: 53.62
+	Hs
		932156 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		ACTC_HUMAN (5-376): 0: 577: 53.72
+	Ce
		501479 Q95QG4_CAEEL (411-693): 9.33e-25: 110: 29.33		ACT4_CAEEL (8-376): 0: 581: 54.42
+	Hs
		554290 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		ACTA_HUMAN (5-376): 0: 576: 53.46
+	Ce
		109402 H2KY94_CAEEL (465-688): 3.39e-25: 107: 33.48		ACT4_CAEEL (8-376): 0: 581: 54.42
+	Hs
		891853 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ACTB_HUMAN (8-376): 0: 581: 53.62
+	Hs
		929905 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ACTG_HUMAN (7-376): 0: 581: 53.74
+	Ce
		137705 O02592_CAEEL (353-709): 5.66e-13: 73.8: 21.29		ACT4_CAEEL (8-376): 0: 581: 54.42
+	Hs
		932219 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ACTC_HUMAN (5-376): 0: 577: 53.72