HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	12888622, 16606369, 22535953
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0007611 - learning or memory and 1 others more... GO:0043025 - neuronal cell body
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 277
+	Hs
		496654 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35
+	Hs
		496655 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP6_HUMAN (10-276): 2.26e-103: 304: 38.57
+	Hs
		496497 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP2_HUMAN (30-276): 7.42e-94: 285: 28.52
+	Hs
		497029 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP8_HUMAN (25-275): 8.12e-93: 283: 35.32
+	Hs
		496377 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP1_HUMAN (2-276): 3.37e-78: 244: 26.26
+	Hs
		788201 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00
+	Hs
		496414 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASPE_HUMAN (28-275): 2.87e-69: 216: 30.08