HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASP2 (P42575)
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Gene: CASP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	37086756
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0019899 - enzyme binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 452
+	Hs
		496377 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP1_HUMAN (32-449): 1.66e-133: 392: 23.29
+	Hs
		497029 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP8_HUMAN (32-446): 1.84e-120: 361: 21.29
+	Hs
		496654 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP7_HUMAN (132-445): 3.79e-112: 334: 26.98
+	Hs
		496496 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP3_HUMAN (188-446): 3.26e-108: 323: 28.85
+	Hs
		496655 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP6_HUMAN (168-447): 1.12e-105: 317: 25.98
+	Hs
		496414 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASPE_HUMAN (182-445): 6.02e-72: 228: 27.44
+	Hs
		788201 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CASP3_HUMAN (188-446): 3.26e-108: 323: 28.85