HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: VDAC2 (P45880)
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
Gene: VDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0045121 - membrane raft
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 294
+	Hs
		2006 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		A0A0A0MR02_HUMAN (1-282): 1.16e-118: 343: 100.00
+	Hs
		496297 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		VDAC1_HUMAN (12-294): 1.42e-110: 323: 74.56
+	Hs
		497832 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		VDAC3_HUMAN (12-294): 1.21e-108: 318: 73.50
+	Rn
		581979 TAU_RAT (1-758): 4.86e-75: 260: 71.47		VDAC2_RAT (8-294): 1.47e-121: 351: 96.52
+	Rn
		94202 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		VDAC2_RAT (8-294): 1.47e-121: 351: 96.52
+	Rn
		582043 TAU_RAT (1-758): 4.86e-75: 260: 71.47		VDAC3_RAT (12-294): 9.89e-110: 320: 72.79
+	Rn
		94267 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		VDAC3_RAT (12-294): 9.89e-110: 320: 72.79
+	Mm
		498040 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		VDAC1_MOUSE (12-294): 1.63e-111: 325: 74.21
+	Mm
		498039 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		VDAC3_MOUSE (12-294): 1.5e-108: 318: 73.85
+	Hs
		330627 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TOM40_HUMAN (12-290): 1.58e-72: 228: 12.63
+	Hs
		799994 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		VDAC2_HUMAN (1-294): 7.18e-126: 362: 100.00
+	Hs
		601247 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		VDAC1_HUMAN (12-294): 1.42e-110: 323: 74.56