HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 858
+	Mm
		497956 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		UBP5_MOUSE (1-858): 0: 844: 98.37
+	Hs
		1056916 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		UBP13_HUMAN (2-858): 0: 721: 59.47
+	Dm
		1370343 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VZU7_DROME (7-855): 0: 631: 48.79
+	Hs
		497398 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		1056917 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		152676 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		1273897 MAGE1_HUMAN (222-587): 4.83e-09: 61.9: 16.22		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		654070 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		UBP21_HUMAN (319-594): 6.55e-24: 109: 22.37
+	Dm
		54344 A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47		UBP36_DROME (326-730): 1.08e-20: 100: 16.04
+	Dm
		1214471 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		UBP2_DROME (321-629): 2.58e-21: 101: 17.73