HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PI42A (P48426)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)
Gene: PIP4K2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010506 - regulation of autophagy
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 406
+	Hs
		496831 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PI42B_HUMAN (11-406): 3.27e-166: 474: 78.30
+	Hs
		56592 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PIPSL_HUMAN (17-403): 3.76e-148: 443: 27.04
+	Hs
		497499 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PI51A_HUMAN (17-403): 3.34e-151: 441: 27.67
+	Hs
		231371 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PI51C_HUMAN (37-403): 1.52e-147: 435: 27.42
+	Hs
		56649 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		PIPSL_HUMAN (17-403): 3.76e-148: 443: 27.04