HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26402096, 26269332, 35063084
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005874 - microtubule GO:0044297 - cell body
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 541
+	Rn
		582014 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TCPE_RAT (1-541): 0: 628: 96.49
+	Rn
		94240 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TCPE_RAT (1-541): 0: 628: 96.49
+	Mm
		498006 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TCPE_MOUSE (1-541): 0: 627: 96.30
+	Hs
		496556 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		497502 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		496254 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Mm
		498007 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TCPG_MOUSE (14-540): 0: 574: 33.33
+	Rn
		582024 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TCPD_RAT (22-534): 0: 546: 38.27
+	Rn
		94250 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TCPD_RAT (22-534): 0: 546: 38.27
+	Dm
		1180666 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q7KKI0_DROME (5-533): 0: 582: 71.46
+	Hs
		496588 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	Dm
		1369257 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VK69_DROME (36-533): 1.12e-109: 338: 41.39