HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KC1A (P48729)
Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)
Gene: CSNK1A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	36634849, 7532213, 9771888, 35063084
Identification Methods	proximity labelling technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 337
+	Hs
		496548 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KC1D_HUMAN (9-306): 4.8e-114: 338: 75.17
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (1-335): 1.7e-112: 336: 16.67
+	Hs
		496248 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCA_HUMAN (5-335): 5.11e-112: 330: 17.46
+	Mm
		397198 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KAPCA_MOUSE (5-335): 2.82e-111: 329: 17.46
+	Hs
		503261 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCA_HUMAN (5-335): 5.11e-112: 330: 17.46
+	Rn
		987567 MAP4_RAT (60-757): 1.97e-10: 66.6: 8.17		KC1D_RAT (9-306): 4.03e-114: 338: 75.17
+	Bt
		337290 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		KAPCA_BOVIN (5-335): 5.73e-111: 328: 17.46