HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TCPQ (P50990)
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)
Gene: CCT8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005874 - microtubule GO:0044297 - cell body
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 548
+	Hs
		497502 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPH_HUMAN (9-538): 0: 564: 26.39
+	Hs
		496556 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		496545 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPE_HUMAN (2-524): 0: 535: 29.62
+	Hs
		496588 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPD_HUMAN (19-525): 0: 530: 28.24
+	Hs
		496254 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Rn
		582024 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TCPD_RAT (2-525): 0: 543: 28.28
+	Rn
		94250 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TCPD_RAT (2-525): 0: 543: 28.28
+	Mm
		498007 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TCPG_MOUSE (10-547): 0: 557: 27.66
+	Rn
		582014 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TCPE_RAT (2-524): 0: 530: 28.87
+	Rn
		94240 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TCPE_RAT (2-524): 0: 530: 28.87
+	Mm
		498006 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TCPE_MOUSE (2-524): 0: 529: 29.06
+	Dm
		1179643 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q7K3J0_DROME (1-544): 0: 553: 61.65
+	Mm
		497911 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TCPA_MOUSE (31-529): 2e-67: 229: 30.71