HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	17512525
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 740
+	Hs
		497071 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		270366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A5_HUMAN (47-734): 0: 703: 40.86
+	Hs
		1057021 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		KS6A6_HUMAN (1-740): 0: 771: 76.54
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		496317 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6B1_HUMAN (397-727): 8.14e-116: 361: 25.50
+	Hs
		496248 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		496307 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCB_HUMAN (409-714): 3.04e-116: 355: 29.15
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		503261 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		503264 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCB_HUMAN (409-714): 3.04e-116: 355: 29.15
+	Bt
		337290 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		KAPCA_BOVIN (409-714): 3.92e-116: 355: 28.53
+	Hs
		116961 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGK1_HUMAN (428-724): 5.73e-27: 116: 29.36