HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	35063084, 15546861, 16262633, 12435421
Identification Methods	proximity labelling technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010288 - response to lead ion and 1 others more... GO:0051879 - Hsp90 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 499
+	Mm
		498036 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PPP5_MOUSE (1-499): 0: 571: 97.80
+	Hs
		496809 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		496758 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	Hs
		496456 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		496730 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09
+	Hs
		496729 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Mm
		497999 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP2AA_MOUSE (190-481): 7.01e-167: 475: 40.88
+	Mm
		592768 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		PPP5_MOUSE (1-499): 0: 571: 97.80
+	Mm
		497972 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP1A_MOUSE (200-479): 2.47e-154: 444: 38.79
+	Mm
		497993 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP1G_MOUSE (196-488): 1.32e-154: 444: 36.88
+	Mm
		88457 D3Z656_MOUSE (72-555): 1.33e-11: 70.4: 11.56		PPP5_MOUSE (1-499): 0: 571: 97.80
+	Dm
		1366837 Q9VPR2_DROME (127-757): 2.65e-20: 98.2: 10.23		Q9VH81_DROME (4-494): 8.41e-179: 513: 59.60
+	Dm
		54320 A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47		Q8T0U6_DROME (144-479): 8.62e-163: 470: 34.22
+	Hs
		930846 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		653952 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Mm
		649202 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		PP1A_MOUSE (200-479): 2.47e-154: 444: 38.79
+	Hs
		905894 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Bt
		664292 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		PP2AA_BOVIN (190-481): 5.28e-167: 475: 40.88
+	Dm
		113980 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		PP1B_DROME (196-484): 2.83e-150: 434: 37.24
+	Mm
		906349 TARA_MOUSE (3-751): 2.63e-09: 63.2: 8.51		PP1A_MOUSE (200-479): 2.47e-154: 444: 38.79