HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MK12 (P53778)
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
Gene: MAPK12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15632108
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 367
+	Hs
		496330 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK2_HUMAN (24-317): 4.02e-147: 419: 36.00
+	Hs
		497100 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK14_HUMAN (5-363): 4.78e-145: 416: 61.56
+	Hs
		496371 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK01_HUMAN (13-357): 2.07e-141: 407: 40.63
+	Hs
		497084 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK11_HUMAN (1-364): 3.89e-141: 406: 62.36
+	Hs
		173819 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK13_HUMAN (8-361): 1.94e-137: 397: 65.92
+	Hs
		496357 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK03_HUMAN (14-353): 2.84e-136: 394: 42.08
+	Rn
		581973 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MK01_RAT (13-357): 1.6e-141: 407: 40.63
+	Rn
		94196 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MK01_RAT (13-357): 1.6e-141: 407: 40.63
+	Mm
		497992 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		MK01_MOUSE (13-357): 1.6e-141: 407: 40.63
+	Hs
		496514 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK09_HUMAN (9-366): 2.83e-108: 325: 45.46
+	Hs
		496629 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK10_HUMAN (11-366): 1.25e-106: 322: 45.16
+	Hs
		496513 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK08_HUMAN (9-367): 3.51e-105: 317: 44.00
+	Hs
		1082653 MUC12_HUMAN (15-752): 1.81e-12: 73.5: 8.54		MK14_HUMAN (5-363): 4.78e-145: 416: 61.56
+	Rn
		926487 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		MK01_RAT (13-357): 1.6e-141: 407: 40.63
+	Hs
		1082593 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		MK14_HUMAN (5-363): 4.78e-145: 416: 61.56
+	Rn
		926474 MAP4_RAT (60-757): 1.97e-10: 66.6: 8.17		MK01_RAT (13-357): 1.6e-141: 407: 40.63