HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MK10 (P53779)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Gene: MAPK10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15228592
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 464
+	Hs
		496514 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK09_HUMAN (39-464): 1.45e-163: 469: 83.80
+	Hs
		496513 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK08_HUMAN (39-464): 5.15e-162: 465: 90.87
+	Hs
		496330 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41
+	Hs
		496628 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK12_HUMAN (40-416): 8.22e-134: 391: 43.95
+	Hs
		173819 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK13_HUMAN (43-411): 3.49e-133: 390: 45.55
+	Hs
		497084 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK11_HUMAN (47-401): 3.53e-133: 390: 47.21
+	Hs
		497100 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK14_HUMAN (42-408): 2.57e-133: 390: 45.95
+	Hs
		496357 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK03_HUMAN (58-397): 1.2e-84: 266: 42.12
+	Hs
		496371 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Rn
		581973 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MK01_RAT (53-397): 1.25e-84: 266: 42.37
+	Rn
		94196 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MK01_RAT (53-397): 1.25e-84: 266: 42.37
+	Mm
		497992 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		MK01_MOUSE (53-397): 1.25e-84: 266: 42.37
+	Hs
		1082653 MUC12_HUMAN (15-752): 1.81e-12: 73.5: 8.54		MK14_HUMAN (42-408): 2.57e-133: 390: 45.95
+	Hs
		1082593 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		MK14_HUMAN (42-408): 2.57e-133: 390: 45.95
+	Rn
		926487 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		MK01_RAT (53-397): 1.25e-84: 266: 42.37
+	Rn
		600416 MAP4_RAT (60-757): 1.97e-10: 66.6: 8.17		MK03_RAT (58-397): 3.58e-85: 268: 42.41
+	Rn
		926474 MAP4_RAT (60-757): 1.97e-10: 66.6: 8.17		MK01_RAT (53-397): 1.25e-84: 266: 42.37