HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12888622
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 303
+	Hs
		496496 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		496655 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP6_HUMAN (56-301): 5.33e-104: 307: 38.28
+	Hs
		496497 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP2_HUMAN (54-301): 2.1e-96: 293: 29.12
+	Hs
		497029 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		496377 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP1_HUMAN (1-301): 8.45e-79: 246: 21.04
+	Hs
		496414 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASPE_HUMAN (57-301): 5.41e-70: 218: 28.11
+	Hs
		788201 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03